Check out this publication on how scaling bovine viral vaccine production can be enabled using Microcarriers: Vaccination remains the most effective method for controlling and preventing diseases, ensuring the safe trade of live animals. The manufacturing of viral vaccines, however, comes with specific challenges, particularly due to the demands of the cell substrates and [...]

Adeno-associated virus (AAV) vectors are at the forefront of gene therapy, offering great potential for treating a variety of genetic disorders. However, a significant challenge in the field is the limited production capacity of these vectors. Higher specific yields of AAV vectors are often achieved using adherent cell systems compared to suspension cultures, and [...]

Introduction Recent research has shed light on the crucial factors affecting myoblast regeneration, a key process in muscle repair. Myoblasts, the precursor cells to muscle fibers, are subjected to mechanical forces such as shear stress during muscle regeneration. This study aimed to explore how these mechanical forces, combined with changes in the extracellular matrix (ECM) [...]

A recent publication titled "Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks" in the Journal of Biotechnological Products and Process Engineering addresses a critical challenge in gene-modified cell therapy: developing scalable manufacturing methods for clinical applications. Human mesenchymal stromal cells (hMSCs) are known for their immunomodulatory properties and in [...]

Cancer treatment faces a multitude of challenges, notably the variation in tumor behavior across different patients. This heterogeneity necessitates personalized approaches to treatment that can adapt to the unique characteristics of each patient’s cancer. Recently, a review article shed light on innovative laboratory models that could be key to advancing these personalized treatments: organoids [...]

Mandarin fish (Siniperca chuatsi) holds a crucial position in China's aquaculture industry. Yet, the persistent threats posed by Infectious Spleen and Kidney Necrosis Virus (ISKNV) and Siniperca Chuatsi Rhabdovirus (SCRV) have hampered its growth potential. Vaccination stands as the most potent defense, but its efficacy hinges on large-scale cell culture—a challenge until now. In [...]

Recent research spearheaded by Stanford scholars has shed light on the pioneering use of induced pluripotent stem cells (iPSCs) in cardiac tissue engineering (Link to Source Article). This innovative approach not only promises to revolutionize our understanding of cardiovascular diseases but also paves the way for new therapeutic strategies. Here’s what you need to [...]

Induced pluripotent stem cells (iPSCs) represent a cornerstone in regenerative medicine and biotechnological research. These versatile cells are generated from somatic cells and can differentiate into nearly any cell type, making them invaluable for applications such as disease modeling, drug testing, and potentially, organ regeneration. Recognizing their potential, the European Bank for induced pluripotent [...]

A recent review publication has shed light on the monumental potential of functional polymer surfaces in steering cell behavior, marking a significant advancement in the realms of biomedical engineering, tissue engineering, and cell-based assays. This paper, freely accessible online, delves into the critical role [...]