The Impact of ECM Stiffness on MSC Differentiation – Why Stiffness Matters in Your Cell Culture
The mechanical properties of the extracellular matrix (ECM) play a crucial role in directing stem cell fate. According to the research by Na et al. (2024), published in Biomaterials, mesenchymal stem cells (MSCs) cultured on ECMs with different stiffness levels show significant differences in chromatin organisation and gene expression, ultimately driving lineage-specific differentiation.This study provides [...]