Poly(ethylene glycol) diacrylate (PEGDA) Hydrogel

Poly(ethylene glycol) diacrylate (PEGDA) is a widely used photocrosslinkable hydrogel for 3D cell culture, tissue engineering, and bioprinting. It is based on polyethylene glycol (PEG) and modified with acrylate groups, allowing fast and controlled light-based crosslinking.

At Smart MCs, PEGDA is available in multiple molecular weights (PEGDA-400, PEGDA-600, PEGDA-1000), giving flexibility to tune mechanical properties and hydrogel structure.

For research use only. Not intended for human clinical applications.

 

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Description

Why use PEGDA?

PEGDA is often used as a “blank slate” hydrogel, meaning it is biologically inert and highly controllable. This makes it ideal for studying cell behaviour without interference from the material itself.

It’s commonly used for:

  • 3D cell culture
  • Tissue engineering scaffolds
  • 3D bioprinting and biofabrication
  • Drug delivery and controlled release
  • Microfluidics and photolithography

Because PEGDA does not naturally support cell attachment, it can be modified with peptides or other biomolecules depending on the application.

Available options

We offer PEGDA in three standard molecular weights:

  • PEGDA-400 (low molecular weight)
    Lower viscosity and higher crosslinking density. Forms tighter, stiffer hydrogels with smaller mesh size. Often used for coatings, microfluidics, and controlled release systems.
  • PEGDA-600 (medium molecular weight)
    A balanced option with moderate flexibility and swelling. Suitable for general hydrogel systems, cell encapsulation, and soft tissue models.
  • PEGDA-1000 (high molecular weight)
    Produces softer, more elastic hydrogels with increased permeability. Commonly used for 3D cell culture and tissue engineering applications.

At room temperature, PEGDA may be liquid or semi-solid depending on molecular weight. Higher molecular weight variants may require gentle warming before use.

Performance

PEGDA is designed for consistent and predictable hydrogel formation.

  • Rapid curing under visible light (e.g. ~405 nm)
  • Tunable stiffness and permeability depending on formulation
  • Suitable for high-resolution fabrication and bioprinting
  • Stable hydrogel formation with reproducible results

Detailed characterisation data is available on request.

Custom options

We can modify PEGDA to suit your application, including:

  • Functionalisation with cell adhesion peptides
  • Composite hydrogel systems (e.g. PEGDA + GelMA)
  • Tailored mechanical or transport properties
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Additional information

Material

Poly(ethylene glycol) diacrylate (PEGDA)

Grade

Research use only

Material Grade

Research Use Only

Appearance:

PEGDA-400: Liquid at 25°C, liquid at 4°C
PEGDA-600: Liquid at 25°C, semi-solid at 4°C
PEGDA-1000: Semi-solid at 25°C, semi-solid at 4°C

Digestibility

Enzymatically degradable (depending on formulation)

Certificate of Analysis

Available upon request

SDS

Available upon request

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