Silk Fibroin Methacryloyl (SilkMA)

Silk Fibroin Methacryloyl comprises methacryloyl-modified silk fibroin and the photoinitiator LAP, tailored for applications in cell culture, biologic 3D printing, and tissue engineering. It is designated exclusively for scientific research and is not intended for human use.

Custom modofication to the gel can be provided upon request – including peptide or other hydrogel combination.

  • Light Based Cross-Linking

  • Xeno-Free Hydrogel

  • Tuneable Stiffness, Size and Surface Charge




Silk Fibroin (SF) is obtained through the degumming of silk, resulting in a high-molecular-weight polypeptide rich in various amino acids. It features both a hydrophobic (H) and a hydrophilic (L) peptide chain, with their unique amino acid sequences enabling the formation of diverse protein secondary structures. By manipulating these structures, the properties of silk fibroin materials can be tailored, enabling the creation of materials that are high-strength and highly oriented. SF is renowned for its excellent biocompatibility, biodegradability, and high tensile strength, making it a preferred choice in biomedical applications like wound dressings, artificial blood vessels, and cell culture.

Methacrylated silk fibroin, known as Silk Fibroin Methacryloyl (SilMA), is produced by modifying SF with glycidyl methacrylate, introducing double bonds into the SF molecule. This modification alters the SF’s spatial structure, transforming it from a crystal that’s challenging to dissolve in water to a material that can easily be dissolved and subsequently photocured into a hydrogel. This process enhances SilMA’s utility in various applications by facilitating its use in forming hydrogels.

Silk fibroin solution behaves as a semi-stable sol that can be prompted to undergo molecular self-assembly, leading to precipitation or gelation when exposed to external stimuli like strong shearing, ultrasound, high temperature, or organic solvents. The presence of a small amount of insoluble material within the silk fibroin solution is typical. To prevent the unintended precipitation of additional silk fibroin, it is advised to eliminate any insoluble matter through methods such as centrifugation or filtration.

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Additional information


Cell Culture, 3D Bioprinting, Tissue Engineering etc.

Matrix Composition

Silk Fibroin Methacryloyl (SilMA)

Material Grade

Research Use Only

Surface Charge




Certicate of Analysis



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