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So far John has created 32 blog entries.

Scalable Manufacturing of Gene-Modified Human Mesenchymal Stromal Cells with Microcarriers in Spinner Flasks

A recent publication titled "Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks" in the Journal of Biotechnological Products and Process Engineering addresses a critical challenge in gene-modified cell therapy: developing scalable manufacturing methods for clinical applications. Human mesenchymal stromal cells (hMSCs) are known for their immunomodulatory properties and in [...]

By |2024-05-31T07:47:59+00:00May 31st, 2024|General News|0 Comments

Exploring Cutting-Edge Cancer Treatment Models: The Role of Organoids and Organs-on-a-Chip

Cancer treatment faces a multitude of challenges, notably the variation in tumor behavior across different patients. This heterogeneity necessitates personalized approaches to treatment that can adapt to the unique characteristics of each patient’s cancer. Recently, a review article shed light on innovative laboratory models that could be key to advancing these personalized treatments: organoids [...]

By |2024-05-12T05:11:53+00:00May 12th, 2024|General News|0 Comments

Large-Scale Microcarrier Culture for Animal Viral Vaccine Production

Mandarin fish (Siniperca chuatsi) holds a crucial position in China's aquaculture industry. Yet, the persistent threats posed by Infectious Spleen and Kidney Necrosis Virus (ISKNV) and Siniperca Chuatsi Rhabdovirus (SCRV) have hampered its growth potential. Vaccination stands as the most potent defense, but its efficacy hinges on large-scale cell culture—a challenge until now. In [...]

By |2024-05-04T02:42:48+00:00May 4th, 2024|General News|0 Comments

Smart MCs Announces New Partnership with Macquarie University

We are thrilled to share exciting news at Smart MCs! A pioneering partnership has been forged with Macquarie University, focusing on the development of an AI-based predictive model for the reliability assessment of microcarriers. This collaborative project is part of a pilot research initiative, generously funded by both Smart MCs and Macquarie University under the [...]

By |2024-04-26T06:41:47+00:00April 26th, 2024|Smart MCs' News|0 Comments

Reconstructing the Heart with iPSCs: Insights and Innovations

Recent research spearheaded by Stanford scholars has shed light on the pioneering use of induced pluripotent stem cells (iPSCs) in cardiac tissue engineering (Link to Source Article). This innovative approach not only promises to revolutionize our understanding of cardiovascular diseases but also paves the way for new therapeutic strategies. Here’s what you need to [...]

By |2024-04-21T03:16:23+00:00April 21st, 2024|General News|0 Comments

Scalable Expansion of iPSCs Technology Using Microcarrier Cultures

Induced pluripotent stem cells (iPSCs) represent a cornerstone in regenerative medicine and biotechnological research. These versatile cells are generated from somatic cells and can differentiate into nearly any cell type, making them invaluable for applications such as disease modeling, drug testing, and potentially, organ regeneration. Recognizing their potential, the European Bank for induced pluripotent [...]

By |2024-04-12T09:31:16+00:00April 12th, 2024|General News|0 Comments

The Power of Functional Polymer Surfaces in Controlling Cell Behaviors

A recent review publication has shed light on the monumental potential of functional polymer surfaces in steering cell behavior, marking a significant advancement in the realms of biomedical engineering, tissue engineering, and cell-based assays. This paper, freely accessible online, delves into the critical role [...]

By |2024-04-05T07:53:37+00:00April 5th, 2024|General News|0 Comments

Enhancing the Palatability of Cultivated Meat: A Review

We are pleased to announce the publication of a significant review by our very own Dr. Christopher J. O'Keeffe, in collaboration with esteemed scientists from the University of Sydney, University of New South Wales, and University of the Sunshine Coast. This review, published in the prestigious journal Trends in Biotechnology, focuses on a crucial aspect [...]

By |2024-03-29T06:22:18+00:00March 29th, 2024|General News, Smart MCs' News|0 Comments

Revolutionising Vaccine Manufacturing: Insights from a Study on Microcarrier-Based Cell Culture

In the realm of biotechnology, the quest for more efficient methods to cultivate cells for vaccine production is ongoing. A recent paper titled "Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling" has offered a promising breakthrough that could significantly enhance the scalability and efficiency of viral [...]

By |2024-03-22T08:54:10+00:00March 22nd, 2024|General News|0 Comments

Boosting Clinical Stem Cell Production: Smart MCs’ Leap Forward with TIA Grant

Sydney's biomaterials leader, Smart MCs PTY LTD, was selected fora notable grant from Therapeutic Innovation Australia (TIA) to explore the potential of novel microcarriers in scaling up the production of Mesenchymal Stem Cells (MSCs) for clinical use. This project is a collaborative effort with the team of Dr. Zlatibor Velickovic at Cell & Tissue Therapies [...]

By |2024-03-15T06:07:37+00:00March 15th, 2024|Smart MCs' News|0 Comments


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