In the realm of biomedical engineering and bio-MEMS, the innovation of organs-on-chips (OoCs) stands as a monumental leap forward, merging the capabilities of labs-on-chips (LOCs) with advanced cell biology to revolutionize our understanding of human physiology. At Smart MCs, we are at the forefront of this technology, crafting versatile systems designed to accurately model and maintain the microenvironments of miniature tissues within microfluidic chips. Our organ-on-a-chip technology encompasses a multi-channel, 3-D microfluidic cell culture chip that emulates the functions, dynamics, and responses of entire organs or organ systems.
This technology serves as a more sophisticated approximation of complex tissues compared to traditional cell cultures, offering a potential alternative to animal testing in pharmaceutical research and toxicology. Despite the technology still being in the nascent stages of development, our OoCs have shown promise in simulating a wide array of human organs, including the brain, lung, heart, kidney, liver, and more, each varying in design and approach to cater to specific research needs.
Smart MCs’ organs-on-chips not only facilitate the detailed study of human physiology in an organ-specific context but also enable researchers to explore the intricate pathophysiology of human diseases, such as viral hepatitis, through platforms like the liver chip. By replicating the physical and biochemical environments of human tissues, our organ-on-a-chip systems provide invaluable insights into organ functions, interactions, and responses to pharmaceutical compounds or toxins, heralding a new era in drug development, disease modeling, and personalized medicine.
Leveraging the precision and control offered by microfluidic technology, Smart MCs is committed to advancing biomedical research with our state-of-the-art organ-on-a-chip systems. Whether for academic research, pharmaceutical development, or clinical studies, our OoCs offer a versatile and reliable platform to explore the vast complexities of human biology, paving the way for groundbreaking discoveries and innovations in healthcare.
| Applications | Drug Discovery and Development: Accelerating the process of screening potential drug compounds by simulating human physiological responses, reducing reliance on animal models, and identifying side effects early in the development process. Disease Modeling: Creating accurate models of human diseases within specific organ contexts to study their pathophysiology and progression, enabling the exploration of therapeutic interventions. Toxicology Testing: Evaluating the safety and efficacy of new compounds, chemicals, and cosmetics without the ethical concerns associated with animal testing. Personalized Medicine: Developing patient-specific models using cells derived from individual patients to test how a particular disease would respond to different treatments, paving the way for tailored therapies. Pharmacokinetics and Pharmacodynamics (PK/PD) Studies: Analyzing how drugs are absorbed, distributed, metabolized, and excreted in the human body, as well as their biochemical and physiological effects. Viral Infection Studies: Investigating the mechanisms of human viral infections, such as hepatitis and COVID-19, within an organ-specific microenvironment to develop targeted antiviral treatments. Regenerative Medicine and Tissue Engineering: Advancing the field by studying stem cell behaviors and tissue regeneration within a controlled microenvironment, contributing to the development of organ transplants and repair strategies. Cancer Research: Modeling tumor growth, metastasis, and the tumor microenvironment to understand cancer progression and test anticancer therapies. Immunology Studies: Exploring immune responses and inflammation within specific organs to understand autoimmune diseases and develop immunotherapies. Nutritional Studies and Gut Microbiome Research: Simulating the human gastrointestinal system to study the effects of diet, nutrients, and microbiota on human health and disease. Blood-Brain Barrier (BBB) Studies: Investigating the transport of drugs and pathogens across the BBB to develop treatments for neurological diseases. Vascular Function and Atherosclerosis Research: Understanding the dynamics of blood flow and the development of vascular diseases to identify potential therapeutic targets. |
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| Device Material | PDMS |
| Sterility | Upon Request: Autoclave & Gamma Irradiation |
| Certicate of Analysis | Yes |
