We are pleased to announce the publication of a significant review by our very own Dr. Christopher J. O'Keeffe, in collaboration with esteemed scientists from the University of Sydney, University of New South Wales, and University of the Sunshine Coast. This review, published in the prestigious journal Trends in Biotechnology, focuses on a crucial aspect [...]
In the realm of biotechnology, the quest for more efficient methods to cultivate cells for vaccine production is ongoing. A recent paper titled "Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling" has offered a promising breakthrough that could significantly enhance the scalability and efficiency of viral [...]
Sydney's biomaterials leader, Smart MCs PTY LTD, was selected fora notable grant from Therapeutic Innovation Australia (TIA) to explore the potential of novel microcarriers in scaling up the production of Mesenchymal Stem Cells (MSCs) for clinical use. This project is a collaborative effort with the team of Dr. Zlatibor Velickovic at Cell & Tissue Therapies [...]
Human embryonic kidney 293 (HEK293) cells are widely utilised in research and bioprocessing industries, yet scaling up their growth poses significant challenges. Check out the 2020 study by Iuchi et al., published in Cytotechnology, which delves into the various morphologies of human embryonic kidney 293T cells in [...]
In a significant leap towards advancing stem cell research and biotechnology, Smart MCs PTY LTD is thrilled to announce its collaboration with Associate Professor Khoon Lim on a groundbreaking project, "Designing Biofunctional Microcarriers for Stem Cell Expansion." This initiative has successfully secured seed funding from the University of Sydney's Faculty of Engineering Seed Funding [...]
Microcarrier Innovations: Paving the Way for Large-Scale Mesenchymal Stromal Cell Expansion A recent review published in the Journal of Trends in Biotechnology highlights the critical advancements and challenges in the field of mesenchymal stromal cell (MSC) expansion through microcarrier technology (Read More - DOI: 10.1016/j.tibtech.2024.01.001). With advancements in cellular therapy, the crucial need for [...]
Publication Title: "High-Titer Manufacturing of SARS-CoV-2 Spike-Pseudotyped VSV in Stirred-Tank Bioreactors: A Leap in Vaccine Production Technology". DOI: 10.1016/j.omtm.2024.101189 In a significant advancement for vaccine production technology, a recent article published in the journal of Methods & Clinical Development (Cell Press) has outlined the efficacy of microcarrier systems in stirred-tank bioreactors for the production of [...]
Production of recombinant adeno-associated virus vectors using microcarrier culture of HEK293T cells The study conducted by Yongfa Lan, HaiRui Yang, and QingRui You from Obio Technology, commissioned by Cytiva, presents a comprehensive comparison of producing adeno-associated virus (AAV) using different cell culture methods, specifically focusing on the use of microcarriers versus traditional flask culture [...]
Dive into the world of cell therapy development and manufacturing with the latest episode of Smart Biotech Scientist Podcast with our very own Prof. Steve Oh: This week, David was joined by Steve Oh, Scientific Advisor and ex-A*STAR Professor, who brings a wealth of knowledge from his extensive experience in biotechnology. Steve will offer [...]
