A recent publication titled "Scalable manufacturing of gene-modified human mesenchymal stromal cells with microcarriers in spinner flasks" in the Journal of Biotechnological Products and Process Engineering addresses a critical challenge in gene-modified cell therapy: developing scalable manufacturing methods for clinical applications. Human mesenchymal stromal cells (hMSCs) are known for their immunomodulatory properties and in [...]

Cancer treatment faces a multitude of challenges, notably the variation in tumor behavior across different patients. This heterogeneity necessitates personalized approaches to treatment that can adapt to the unique characteristics of each patient’s cancer. Recently, a review article shed light on innovative laboratory models that could be key to advancing these personalized treatments: organoids [...]

Mandarin fish (Siniperca chuatsi) holds a crucial position in China's aquaculture industry. Yet, the persistent threats posed by Infectious Spleen and Kidney Necrosis Virus (ISKNV) and Siniperca Chuatsi Rhabdovirus (SCRV) have hampered its growth potential. Vaccination stands as the most potent defense, but its efficacy hinges on large-scale cell culture—a challenge until now. In [...]

Recent research spearheaded by Stanford scholars has shed light on the pioneering use of induced pluripotent stem cells (iPSCs) in cardiac tissue engineering (Link to Source Article). This innovative approach not only promises to revolutionize our understanding of cardiovascular diseases but also paves the way for new therapeutic strategies. Here’s what you need to [...]

Induced pluripotent stem cells (iPSCs) represent a cornerstone in regenerative medicine and biotechnological research. These versatile cells are generated from somatic cells and can differentiate into nearly any cell type, making them invaluable for applications such as disease modeling, drug testing, and potentially, organ regeneration. Recognizing their potential, the European Bank for induced pluripotent [...]

A recent review publication has shed light on the monumental potential of functional polymer surfaces in steering cell behavior, marking a significant advancement in the realms of biomedical engineering, tissue engineering, and cell-based assays. This paper, freely accessible online, delves into the critical role [...]

In the realm of biotechnology, the quest for more efficient methods to cultivate cells for vaccine production is ongoing. A recent paper titled "Seed Train Optimization in Microcarrier-Based Cell Culture Post In Situ Cell Detachment through Scale-Down Hybrid Modeling" has offered a promising breakthrough that could significantly enhance the scalability and efficiency of viral [...]

Human embryonic kidney 293 (HEK293) cells are widely utilised in research and bioprocessing industries, yet scaling up their growth poses significant challenges. Check out the 2020 study by Iuchi et al., published in Cytotechnology, which delves into the various morphologies of human embryonic kidney 293T cells in [...]

In a significant leap towards advancing stem cell research and biotechnology, Smart MCs PTY LTD is thrilled to announce its collaboration with Associate Professor Khoon Lim on a groundbreaking project, "Designing Biofunctional Microcarriers for Stem Cell Expansion." This initiative has successfully secured seed funding from the University of Sydney's Faculty of Engineering Seed Funding [...]